Journal Reviews

American Journal of Otolaryngology cover image.

A new era in the treatment of recalcitrant nasal polyps?

8 November 2021 | | Laryngology / Swallowing / Voice, Rhinology / Sinus | IgE, SNOT-22, aspirin-exacerbated respiratory disease, chronic rhinosinusitis with nasal polyps, mild asthma, nasal polyps, omalizumab, quality of life, tissue eosinophilia, total nasal endoscopic polyp score

Chronic rhinosinusitis with nasal polyps (CRSwNP) can be difficult to treat effectively in patients with aggressive or recalcitrant disease. Omalizumab (Xolair) is a monoclonal anti-IgE antibody with proven benefits for patients with moderate/severe asthma and CRSwNP, but this study looks...

Allergy journal cover image.

COVID-19 in patients with chronic rhinosinusitis with polyps. Are they at risk?

1 July 2021 | | Rhinology / Sinus, COVID-19 | ACE2, SARS-CoV-2, TMPRSS2, chronic rhinosinusitis with nasal polyps, inflammatory endotype

COVID-19 entry factors are highly present in nasal epithelial cells. These factors include ACE2 and TMPRSS2. Their presence in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) was not investigated before. Authors investigated expression of ACE2 and TMPRSS2 in two...